Cardiologist in NSW

Publications

Dr Semsarian has published over 430 peer-reviewed scientific publications in the highest-ranking cardiovascular and general medical journals. For the full list, go to: PubMed. Here’s a list of the latest 30 publications:

1. Soh MS, Hu A, Kuanyshbek A, Mohamed Syazwan ES, Lee HM, McKenzie CE, Phillips AM, Bleakley LE, Semsarian C, Scheffer IE, Berkovic SF, Reid CA. Atenolol rescues premature mortality in genetic mouse models of sudden unexpected death in epilepsy. Epilepsia. 2025 Sep 24. doi: 10.1111/epi.18642. Epub ahead of print. PMID: 40991209.

2. Johnson R, Fletcher RA, Peters S, Ohanian M, Soka M, Smolnikov A, Abihider KE, Ackerman MJ, Ader F, Akhtar MM, Amin AS, Ashley EA, Atherton JJ, Austin R, Baas AF, Bagnall RD, Ross SB, Blouin JL, Brown EE, Bundgaard H, Cannie D, Chmielewski P, Correnti G, Crespo-Leiro MG, Dal Ferro M, Dellefave-Castillo LM, Dominguez F, Dooijes D, Dybro AM, Ed Demri Y, El Hachmi M, Escobar-Lopez L, Foye SJ, Franaszczyk M, Gigli M, Lopez EG, Goudal A, Graw S, Guipponi M, Haan E, Haas J, Hammersley DJ, Hansen FG, Hayward CS, Hey TM, Heymans S, Ho CY, Houweling AC, Ingles J, Ingrey A, Jabbour A, James PA, Jansweijer JA, Jongbloed JDH, Keogh AM, Larrañaga-Moreira JM, Lekanne Deprez RH, Macciocca I, Macdonald PS, Mansencal N, Mansour J, Martinez-Veira C, McDonough B, McGaughran J, Medo K, Merlo M, Michalak E, Monserrat L, Mountain H, Muller SA, Murphy AM, Murray B, Oates EC, Ormondroyd E, Pachter N, Paldino A, Palmyre A, Pereira NL, Picard KC, Poplawski N, Prasad S, Proukhnitzky J, Pruny JF, Reant P, Richard P, Ronan A, Sedaghat-Hamedani F, Semsarian C, Storm G, Stroeks S, Syrris P, Taylor MRG, Thomson K, Thompson T, van Tintelen JP, Vissing CR, Waddell-Smith KE, Wallis M, Zentner D; Australian Genomics Cardiac Flagship; Arnott C, Marian AJ, Oh J, Fokstuen S, James CA, Barriales-Villa R, Meder B, Wahbi K, Giudicessi JR, Parikh VN, Ware JS, Piriou N, Rooryck C, Lakdawala NK, Mestroni L, Sinagra G, Elliott PM, Watkins H, McNally EM, Charron P, van Spaendonck-Zwarts KY, Garcia-Pavia P, Peña-Peña ML, Mogensen J, Christensen AH, Bilińska ZT, Rasmussen TB, Seidman JG, Seidman CE, Te Riele ASJM, Verdonschot JAJ, Pinto YM, Christiaans I, Fatkin D. Titin-related familial dilated cardiomyopathy: factors associated with disease onset. Eur Heart J. 2025 Aug 11:ehaf380. doi: 10.1093/eurheartj/ehaf380. Epub ahead of print. PMID: 40796136.

3. Martins H, Mills JD, Pagni S, Gulcebi MI, Vakrinou A, Moloney PB, Clayton LM, Bellampalli R, Stamberger H, Weckhuysen S, Striano P, Zara F, Bagnall RD, Harris RV, Lawrence KM, Sadleir LG, Crompton DE, Friedman D, Laze J, Li L, Berkovic SF, Semsarian C, Scheffer IE, Devinsky O, Kuchenbaecker K, Balestrini S, Sisodiya SM. SUDEP risk is influenced by longevity genomics: a polygenic risk score study. EBioMedicine. 2025 Aug;118:105841. doi: 10.1016/j.ebiom.2025.105841. Epub 2025 Jul 28. PMID: 40731221; PMCID: PMC12368338.

4. Semsarian C, Medi C. Screening families after sudden cardiac death in the young: do we ever stop? Europace. 2025 Jul 1;27(7):euaf141. doi: 10.1093/europace/euaf141. PMID: 40667716; PMCID: PMC12264590.

5. Shetty NS, Pampana A, Gaonkar M, Patel N, Vekariya N, Smith JG, Kalra R, Chahal CAA, Semsarian C, Li P, Arora G, Arora P. Association of Pathogenic/Likely Pathogenic Genetic Variants for Cardiomyopathies With Clinical Outcomes: A Multiancestry Analysis in the All of Us Research Program. Circ Genom Precis Med. 2025 Jun;18(3):e005113. doi: 10.1161/CIRCGEN.124.005113. Epub 2025 May 28. PMID: 40433684.

6. Hespe S, Singer ES, Reuter C, Murray B, Jordan E, Chowns J, Peters S, Mayers M, Gray B, Hershberger RE, Owens AT, Semsarian C, Waddell A, Asatryan B, Owens E, Thaxton C, Adduru ML, Anderson K, Brown EE, Hoffman-Andrews L, Stafford F, Bagnall RD, Bronicki L, Callewaert B, Chahal CAA, James CA, Jarinova O, Landstrom AP, McNally EM, Muiño-Mosquera L, Parikh V, Walsh R, Wayburn B, Ware JS, Parker BL, Porrello ER, Elliott DA, McNamara JW, Ingles J. Clinical Validity of Autosomal Dominant ALPK3 Loss-of-Function Variants as a Cause of Hypertrophic Cardiomyopathy. Circ Genom Precis Med. 2025 Jun;18(3):e004976. doi: 10.1161/CIRCGEN.124.004976. Epub 2025 Apr 21. PMID: 40255155.

7. Munot S, Redfern J, Bray JE, Angell B, Coggins A, Denniss AR, Jennings G, Khanlari S, Kovoor P, Kumar S, Lai K, Marschner S, Middleton PM, Oppermann I, Rock Z, Semsarian C, Vukasovic M, Bauman A, Chow CK. FirstCPR: A pragmatic community organisation-based cluster randomised trial to increase community training and preparedness to respond to out-of-hospital cardiac arrest. Resusc Plus. 2025 Mar 27;23:100949. doi: 10.1016/j.resplu.2025.100949. PMID: 40248165; PMCID: PMC12005295.

8. Leinhos L, Robinson P, Poloni G, Broadway-Stringer S, Beglov J, Lokman AB, Douglas G, Nuthay S, Fonseka O, Schmid M, Singer E, Hooper C, Thomson K, Bagnall RD, Ingles J, Semsarian C, Ormondroyd E, Toepfer CN, Davies B, Redwood C, Watkins H, Gehmlich K. An ALPK3 truncation variant causing autosomal dominant hypertrophic cardiomyopathy is partially rescued by mavacamten. Sci Rep. 2025 Mar 24;15(1):10090. doi: 10.1038/s41598-025-94371-w. PMID: 40128237; PMCID: PMC11933305.

9. Meisner JK, Renberg A, Smith ED, Tsan YC, Elder B, Bullard A, Merritt OL, Zheng SL, Lakdawala NK, Owens AT, Ryan TD, Miller EM, Rossano JW, Lin KY, Claggett BL, Ashley EA, Michels M, Lampert R, Stendahl JC, Abrams D, Semsarian C, Parikh VN, Wheeler MT, Ingles J, Olivotto I, Day SM, Saberi S, Russell MW, Previs M, Ho CY, Ware JS, Helms AS. Correction to: Low Penetrance Sarcomere Variants Contribute to Additive Risk in Hypertrophic Cardiomyopathy. Circulation. 2025 Mar 18;151(11):e762. doi: 10.1161/CIR.0000000000001318. Epub 2025 Mar 17. Erratum for: Circulation. 2025 Mar 18;151(11):783-798. doi: 10.1161/CIRCULATIONAHA.124.069398. PMID: 40096296.

10. Butters A, Thomson K, Harrington F, Henden N, McGuire K, Byrne AB, Bryen S, McGurk KA, Leask M, Ackerman MJ, Atherton J, Bos JM, Caleshu C, Day SM, Dunn K, Hayes I, Juang J, McGaughran J, Nowak N, Parikh VN, Ronan A, Semsarian C, Tardiff JC, Tiemensma M, Merriman TR, Ware JS, Skinner JR, MacArthur DG, Siggs OM, Bagnall RD, Ingles J. A rare splice-site variant in TNNT2: the need for ancestral diversity in genomic reference data sets. Eur Heart J. 2025 Apr 15;46(15):1446-1449. doi: 10.1093/eurheartj/ehaf001. PMID: 40038847; PMCID: PMC11997547.

11. Butters A, Arnott C, Sweeting J, Claggett B, Cuomo AS, Abrams D, Ashley EA, Day SM, Helms AS, Lampert R, Lin KY, Michels M, Miller EM, Olivotto I, Owens A, Parikh VN, Pereira AC, Rossano JW, Ryan TD, Saberi S, Stendahl JC, Ware JS, Atherton J, Semsarian C, Lakdawala NK, Ho CY, Ingles J. Sex-Specific Clinical and Genetic Factors Associated With Adverse Outcomes in Hypertrophic Cardiomyopathy. Circ Genom Precis Med. 2025 Feb;18(1):e004641. doi: 10.1161/CIRCGEN.124.004641. Epub 2025 Jan 24. PMID: 39851041.

12. Ranpura GN, Holliday M, Li S, Ross SB, Singer ES, Fraser ST, Bagnall RD, Semsarian C, Lim S. Generation of an isogenic CRISPR/Cas9-corrected control induced pluripotent stem cell line from a patient with autosomal dominant catecholaminergic polymorphic ventricular tachycardia with a heterozygous variant in cardiac calsequestrin-2. Stem Cell Res. 2025 Mar;83:103650. doi: 10.1016/j.scr.2024.103650. Epub 2024 Dec 31. PMID: 39826349.

13. Isbister JC, Strocchi M, Riedy M, Yeates L, Gray B, Singer ES, Bagnall RD, Ingles J, Raju H, Semsarian C, Niederer SA, Sy RW. Noninvasive assessment of hydroquinidine effect in Brugada syndrome (QUIET BrS). Heart Rhythm. 2024 Dec 14:S1547-5271(24)03659-2. doi: 10.1016/j.hrthm.2024.12.014. Epub ahead of print. PMID: 39675648.

14. Austin R, Brown JS, Casauria S, Madelli EO, Mattiske T, Boughtwood T, Metke A, Davis A, Horton AE, Winlaw D, Das D, Soka M, Giannoulatou E, Rath EM, Haan E, Blue GM, Vohra J, Atherton JJ, van Spaendonck-Zwarts K, Cox K, Burnett L, Wallis M, Haas M, Quinn MCJ, Pachter N, Poplawski NK, Stark Z, Bagnall RD, Weintraub RG, Pantaleo SJ, Lunke S, De Fazio P, Thompson T, James P, Chang Y, Fatkin D, Macciocca I, Ingles J, Dunwoodie SL, Semsarian C, McGaughran J; Australian Genomics Cardiovascular Disorders Flagship. A multitiered analysis platform for genome sequencing: Design and initial findings of the Australian Genomics Cardiovascular Disorders Flagship. Genet Med Open. 2024 Mar 25;2:101842. doi: 10.1016/j.gimo.2024.101842. PMID: 39669597; PMCID: PMC11613726.

15. Meisner JK, Renberg A, Smith ED, Tsan YC, Elder B, Bullard A, Merritt OL, Zheng SL, Lakdawala NK, Owens AT, Ryan TD, Miller EM, Rossano JW, Lin KY, Claggett BL, Ashley EA, Michels M, Lampert R, Stendahl JC, Abrams D, Semsarian C, Parikh VN, Wheeler MT, Ingles J, Olivotto I, Day SM, Saberi S, Russell MW, Previs M, Ho CY, Ware JS, Helms AS. Low Penetrance Sarcomere Variants Contribute to Additive Risk in Hypertrophic Cardiomyopathy. Circulation. 2025 Mar 18;151(11):783-798. doi: 10.1161/CIRCULATIONAHA.124.069398. Epub 2024 Dec 5. Erratum in: Circulation. 2025 Mar 18;151(11):e762. doi: 10.1161/CIR.0000000000001318. PMID: 39633578; PMCID: PMC11913586.

16. Patel N, Shetty NS, Pampana A, Gaonkar M, Vekariya N, Li P, Owens AT, Semsarian C, Arora G, Arora P. Sex-Associated Differences in Clinical Outcomes After Septal Reduction Therapies in Hypertrophic Cardiomyopathy. Mayo Clin Proc. 2024 Dec;99(12):1933-1944. doi: 10.1016/j.mayocp.2024.05.026. Epub 2024 Nov 12. PMID: 39530964; PMCID: PMC11727816.

17. Isbister JC, Tadros R, Raju H, Semsarian C. Concealed cardiomyopathy as an emerging cause of sudden cardiac arrest and sudden cardiac death. Nat Cardiovasc Res. 2024 Nov;3(11):1274-1283. doi: 10.1038/s44161-024-00558-1. Epub 2024 Nov 1. PMID: 39487366.

18. Asatryan B, Murray B, Tadros R, Rieder M, Shah RA, Sharaf Dabbagh G, Landstrom AP, Dobner S, Munroe PB, Haggerty CM, Medeiros-Domingo A, Owens AT, Kullo IJ, Semsarian C, Reichlin T, Barth AS, Roden DM, James CA, Ware JS, Chahal CAA; Genotype‐First Approach Investigators. Promise and Peril of a Genotype-First Approach to Mendelian Cardiovascular Disease. J Am Heart Assoc. 2024 Nov 5;13(21):e033557. doi: 10.1161/JAHA.123.033557. Epub 2024 Oct 18. PMID: 39424414; PMCID: PMC11935662.

19. Healy J, Youssef AM, Sawant S, Orchard JJ, Rehan R, Van Vuuren R, Orchard JW, Semsarian C, Puranik R. Trends in Sudden Unexpected Deaths in an Australian Population: Impact of the COVID-19 Pandemic. Heart Lung Circ. 2024 Dec;33(12):1693-1698. doi: 10.1016/j.hlc.2024.07.009. Epub 2024 Oct 10. PMID: 39389859.

20. Maurizi N, Antiochos P, Owens A, Lakdwala N, Saberi S, Russell MW, Fumagalli C, Skalidis I, Lin KY, Nathan AS, De Feria Alsina A, Reza N, Stendahl JC, Abrams D, Semsarian C, Clagget B, Lampert R, Wheeler M, Parikh VN, Ashley E, Michels M, Rossano J, Ryan TD, Ingles J, Ware J, Ho CY, Helms AS, Day SM, Olivotto I. Long-Term Outcomes After Septal Reduction Therapies in Obstructive Hypertrophic Cardiomyopathy: Insights From the SHARE Registry. Circulation. 2024 Oct 22;150(17):1377-1390. doi: 10.1161/CIRCULATIONAHA.124.069378. Epub 2024 Oct 2. PMID: 39355918; PMCID: PMC11493522.

21. Lim S, Mangala MM, Holliday M, Cserne Szappanos H, Barratt-Ross S, Li S, Thorpe J, Liang W, Ranpura GN, Vandenberg JI, Semsarian C, Hill AP, Hool LC. Reduced connexin-43 expression, slow conduction and repolarisation dispersion in a model of hypertrophic cardiomyopathy. Dis Model Mech. 2024 Aug 1;17(8):dmm050407. doi: 10.1242/dmm.050407. Epub 2024 Aug 27. PMID: 39189070; PMCID: PMC11381919.

22. Semsarian S, Omsland TK, Heen E, Madar AA, Frihagen F, Gjertsen JE, Solberg LB, Figved W, Stutzer JM, Borgen TT, Andreasen C, Hansen AK, Bjørnerem Å, Dahl C. Subsequent fracture risk in Norwegians and immigrants with an index forearm fracture: a cohort study. Arch Osteoporos. 2024 Aug 6;19(1):72. doi: 10.1007/s11657-024-01419-x. PMID: 39107458; PMCID: PMC11303429.

23. Kany S, Jurgens SJ, Rämö JT, Christophersen IE, Rienstra M, Chung MK, Olesen MS, Ackerman MJ, McNally EM, Semsarian C, Schnabel RB, Wilde AAM, Benjamin EJ, Rehm HL, Kirchhof P, Bezzina CR, Roden DM, Shoemaker MB, Ellinor PT. Genetic testing in early-onset atrial fibrillation. Eur Heart J. 2024 Sep 7;45(34):3111-3123. doi: 10.1093/eurheartj/ehae298. PMID: 39028637; PMCID: PMC11379493.

24. Zhang X, Theotokis PI, Li N; SHaRe Investigators; Wright CF, Samocha KE, Whiffin N, Ware JS. Genetic constraint at single amino acid resolution in protein domains improves missense variant prioritisation and gene discovery. Genome Med. 2024 Jul 11;16(1):88. doi: 10.1186/s13073-024-01358-9. PMID: 38992748; PMCID: PMC11238507.

25. Edwards JJ, Compton C, Chatrath N, Petek BJ, Baggish A, Börjesson M, Chung E, Corrado D, Drezner JA, Gati S, Gray B, Kim J, La Gerche A, Malhotra A, Marijon E, Papadakis M, Pelliccia A, Phelan D, Semsarian C, Sharma S, Sharma R, O’Driscoll JM, Harmon KG. International Criteria for Reporting Study Quality for Sudden Cardiac Arrest/Death Tool. J Am Heart Assoc. 2024 Jun 4;13(11):e033723. doi: 10.1161/JAHA.123.033723. Epub 2024 May 23. PMID: 38780180; PMCID: PMC11255648.

26. Writing Committee Members; Ommen SR, Ho CY, Asif IM, Balaji S, Burke MA, Day SM, Dearani JA, Epps KC, Evanovich L, Ferrari VA, Joglar JA, Khan SS, Kim JJ, Kittleson MM, Krittanawong C, Martinez MW, Mital S, Naidu SS, Saberi S, Semsarian C, Times S, Waldman CB. 2024 AHA/ACC/AMSSM/HRS/PACES/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2024 Jun 11;83(23):2324-2405. doi: 10.1016/j.jacc.2024.02.014. Epub 2024 May 8. Erratum in: J Am Coll Cardiol. 2024 Oct 29;84(18):1771. doi: 10.1016/j.jacc.2024.08.055. PMID: 38727647.

27. Ommen SR, Ho CY, Asif IM, Balaji S, Burke MA, Day SM, Dearani JA, Epps KC, Evanovich L, Ferrari VA, Joglar JA, Khan SS, Kim JJ, Kittleson MM, Krittanawong C, Martinez MW, Mital S, Naidu SS, Saberi S, Semsarian C, Times S, Waldman CB; Peer Review Committee Members. 2024 AHA/ACC/AMSSM/HRS/PACES/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation. 2024 Jun 4;149(23):e1239-e1311. doi: 10.1161/CIR.0000000000001250. Epub 2024 May 8. Erratum in: Circulation. 2024 Aug 20;150(8):e198. doi: 10.1161/CIR.0000000000001277. PMID: 38718139.

28. Lynge TH, Albert CM, Basso C, Garcia R, Krahn AD, Semsarian C, Sheppard MN, Behr ER, Tfelt-Hansen J. Autopsy of all young sudden death cases is important to increase survival in family members left behind. Europace. 2024 Jun 3;26(6):euae128. doi: 10.1093/europace/euae128. PMID: 38715537; PMCID: PMC11164113.

29. Munot S, Bray JE, Redfern J, Bauman A, Marschner S, Semsarian C, Denniss AR, Coggins A, Middleton PM, Jennings G, Angell B, Kumar S, Kovoor P, Vukasovic M, Bendall JC, Evens T, Chow CK. Bystander cardiopulmonary resuscitation differences by sex – The role of arrest recognition. Resuscitation. 2024 Jun;199:110224. doi: 10.1016/j.resuscitation.2024.110224. Epub 2024 Apr 27. PMID: 38685374.

30. Lamba A, Roston TM, Peltenburg PJ, Kallas D, Franciosi S, Lieve KVV, Kannankeril PJ, Horie M, Ohno S, Brugada R, Aiba T, Fischbach P, Knight L, Till J, Kwok SY, Probst V, Backhoff D, LaPage MJ, Batra AS, Drago F, Haugaa K, Krahn AD, Robyns T, Swan H, Tavacova T, van der Werf C, Atallah J, Borggrefe M, Rudic B, Sarquella-Brugada G, Chorin E, Hill A, Kammeraad J, Kamp A, Law I, Perry J, Roberts JD, Tisma-Dupanovic S, Semsarian C, Skinner JR, Tfelt-Hansen J, Denjoy I, Leenhardt A, Schwartz PJ, Ackerman MJ, Blom NA, Wilde AAM, Sanatani S. An international multicenter cohort study on implantable cardioverter-defibrillators for the treatment of symptomatic children with catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm. 2024 Oct;21(10):1767-1776. doi: 10.1016/j.hrthm.2024.04.006. Epub 2024 Apr 7. PMID: 38588993.

More publications available at: PubMed